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Fluorination
Organofluoride compounds have become one of the most important and common class of substances among…
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Halogenation of organic compounds using continuous flow and microreactor technology
Abstract The halogenation of organic substrates is one the most important transformations in organic synthesis.…
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Continuous handling of reactions forming solids
We selected two reactions to assess the ability of the CSTR cascade to handle the…
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General procedure for solid-forming reactions in the CSTR cascade
The scheme of the setup for continuous handling of solid-forming reactions in the CSTR cascade…
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Residence time distribution (RTD) characterization
The RTD profiles of the CSTR cascade were obtained using the pulse injection method (Fig.…
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Experimental section
Materials Reagents and chemicals used in this work, including methylene blue, isoprene, maleic acid anhydride,…
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A miniature CSTR cascade for continuous flow of reactions containing solids
Abstract Continuous handling of solids creates challenges for realizing continuous production of pharmaceuticals and fine…
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Chemistry
For the difluoromethylation reaction, the inlets A, B and D were attached with standard connectors…
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Reactor printing and characterization
For the SLM process, the 3D CAD model is dissected by the process software into…
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Reactor design
To accomplish the desired difluoromethylation reaction, three inlets for substrate, nBuLi and CHF3 are required (Fig. 2 and 3).…